Bioactive chemical constituents, acute toxicity and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of Polyalthia longifolia root

Polyalthia longifolia (masquerade tree) is a plant which believed to possess varied pharmacological and therapeutic values among different populations. The present report investigated the phytochemical composition, proximate, acute toxicity antioxidant potential of P. longfolia root. All analyses were carried out using established methods; activity crude methanol extract its fractions (n-hexane ethyl acetate) examined 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay while total phenolic flavonoid contents assessed Folin-Ciocalteu aluminum chloride calibration methods respectively. analysis revealed presence alkaloids, carbohydrate, reducing sugars, tannins, saponins, flavonoids, compounds protein in aqueous extract. proximate showed moisture content, ash, alcohol extractive value, water acid insoluble ash soluble at 8.80, 9.35, 3.28, 3.29, 2.27 7.29% acetate fraction highest property compared n-hexane all assays conducted. Also, was found have flavonoids content fractions. Oral administration Swiss mice relatively non-toxic maximum dose 5000 mg/kg. root indicated moderately high level some phytochemicals with outstanding activity, therefore substantiate use as conventional comparatively antioxidant.